J Hematol

Journal of Hematology, ISSN 1927-1212 print, 1927-1220 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Hematol and Elmer Press Inc

Journal website http://www.thejh.org

Case Report

Volume 5, Number 1, March 2016, pages 34-37

Acquired Hemophilia Secondary to Rheumatoid Arthritis: Case Report and Literature Review

Figures

Figure 1.

Figure 1. Ecchymosis on the hypogastric region.

Figure 2.

Figure 2. Ecchymosis in dorsal region.

Figure 3.

Figure 3. Subaponeurotic hematoma before treatment (arrow).

Figure 4.

Figure 4. Subaponeurotic hematoma after the treatment (arrow).

Tables

**Table 1.** Laboratory Data
Test	Reference	Patient result
Hemoglobin	11.3 - 16.3 g/dL	5.1 g/dL
WBC	4,000 - 10,000/mm³	7,210/mm³
Lymphocytes	1,500 - 4,000/mm³	769/mm³
Platelets	150,000 - 450,000/mm³	264,000/mm³
C- reactive protein	< 5.6 mg/L	106 mg/L
ESR	< 20 mm	67 mm
Albumin	Above 3.5 g/dL	2.8 g/dL
Sodium	135 - 145 mEq/L	137 mEq/L
Potassium	3.5 - 5.5 mEq/L	3.0 mEq/L
Calcium	8.5 - 10.9 mEq/dL	8.2 mg/dL
Creatinine	0.5 - 1.3 mg/dL	0.5 mg/dL
PT	10.7 seg/≤ 1.20	15.1 seg/1.09
aPTT	29.2 seg/≤ 1.25	97.4 seg/2.9

**Table 2.** Serologic Tests
Test	Reference	Patient result
ANA	Negative	Negative
Anticardiolipin IGM	< 7 MPL U/mL	2.0 MPL U/mL
Anticardiolipin IgG	< 10 GPL U/mL	2.0 GPL U/mL
PT	10.7 seg/≤ 1.20	14.7/1.22
aPTT	29.2 seg/≤ 1.25	113.8/3.45
Lupus anticoagulant	Negative	Positive
Beta 2 glycoprotein I IgG	<15 U/mL	1 U/mL
Beta 2 glycoprotein I IgM	< 10 U/mL	1 U/mL
Factor VIII level	60-150%	1%
factor VIII inhibitor	Negative	Positive
Anti-CCP	Inferior to 5.0 U/mL	652.6 U/mL
Rheumatoid factor	Under 20 U/mL	92.5 U/mL