Journal of Hematology, ISSN 1927-1212 print, 1927-1220 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Hematol and Elmer Press Inc
Journal website https://www.thejh.org

Case Report

Volume 12, Number 3, June 2023, pages 118-122

An Aggressive Course of Transformed Splenic Diffuse Red Pulp Small B-Cell Lymphoma With Novel Somatic Loss-of-Function Mutation in RB1

Figures

Figure 1.
Figure 1. (a) Spleen with SDRPL, (b) CD20 (red) and Ki-67 (brown) double stain (DS), (c) CD21-spleen showing minimal follicular dendritic networks, (d) first BM with nodular and interstitial infiltration with small and medium sized lymphocytes, (e) first BM with low proliferations rate in Ki-67 in nodular infiltration, (f) BM with DLBCL, (g) high proliferations rate in DLBCL, and (h) PAX5 with severe BM infiltration from DLBCL. SDRPL: splenic diffuse red pulp small B-cell lymphoma; BM: bone marrow; DLBCL: diffuse large B-cell lymphoma.
Figure 2.
Figure 2. (a) PET-CT at diagnosis with enlarged spleen with inhomogeneous FDG uptake. (b) PET-CT from first relapse with extensive FDG uptake corresponding to the course of the left sciatic nerve. PET-CT: positron emission tomography-computed tomography.