Journal of Hematology, ISSN 1927-1212 print, 1927-1220 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Hematol and Elmer Press Inc
Journal website https://www.thejh.org

Review

Volume 13, Number 3, June 2024, pages 53-60

Sickle Cell Screening in Adults: A Current Review of Point-of-Care Testing

Figures

Figure 1.
Figure 1. Sickle cell solubility test in the laboratory. The presence of hemoglobin S is marked by a turbid solution (on the left). The control solution is clear, allowing for visualization of the lines (right).
Figure 2.
Figure 2. Hemoglobin S (HbS) percentage with concomitant sickle cell solubility testing (SCST) in 220 distinct samples in patients with sickle cell disease (SCD), sickle cell trait (SCT) or HbAA. These samples were taken from 112 patients with SCD of all genotypes, 16 patients with SCT, and one patient without SCD or SCT. SCD patients were further subdivided by genotype: HbSS, HbSC, HbS-beta thalassemia null, or HbS-beta thalassemia positive. Of the 220 samples, five were false negative (large circles). These all occurred at an HbS level < 15%. This subset is highlighted in the blue subsection with individual negative values indicated by the large circles.