Journal of Hematology, ISSN 1927-1212 print, 1927-1220 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Hematol and Elmer Press Inc
Journal website http://www.thejh.org

Original Article

Volume 3, Number 2, June 2014, pages 27-33

Retrospective Analysis of Heparin-Induced Thrombocytopenia Management at a Large Tertiary Hospital

Figures

Figure 1.
Figure 1. HIT work-up by service type. Percentage of patients undergoing work-up for HIT based on what service they were on.
Figure 2.
Figure 2. Use of heparin alternative by service type comparing medical and surgical services (P-value = 0.0395).
Figure 3.
Figure 3. OD values by 4T score. OD values (y-axis) and clinical 4T score (x-axis) with linear regression plot showing increasing OD values with increasing clinical 4T score.

Tables

Table 1. HIT Diagnosis, Test Results and Heparin Alternative Use by Clinical 4T Score
 
Clinical 4T scoreSRA positiveHIT diagnosed (by SRA or Heme/Onc)HIT Ab positiveHIT Ab avg. value (OD units)SRA negative with HIT Ab positiveSRA positive with HIT Ab negativeHeparin alternative used
Shown are the number and percentage of patients by clinical 4T score that had positive SRA, were diagnosed with HIT, had positive HIT ELISA and use of heparin alternatives. The average OD units are also listed by clinical 4T score. *HIT antibody not performed in one patient. †HIT antibody not performed in one patient.
Low (0 - 3) (n = 161) (73.8%)0/36 (0%)1/161 (0.62%)25/160* (15.63%)0.25712/250/229 (5.5%)
Intermediate (4 - 5) (n = 49) (22.5%)0/15 (0%)0/49 (0%)12/48 (25%)†0.3345/120/98 (16.3%)
High (6 - 8) (n = 8) (3.7%)3/5 (60%)4/8 (50%)6/8 (75%)1.682/6N/A6 (75%)
Total3/565/218 (2.29%)43/216N/A19/430/3123

 

Table 2. OD Cut-Offs and Presence of HIT
 
OD < 0.40OD 0.4 to 1.00OD 1.00 to 1.40OD 1.4 to 2.0OD > 2.0
Number of positive and negative SRA tests and percentage of positive SRA based on specific OD cut-off demonstrating the higher proportion of positive SRA at OD values > 2.0.
HIT present (SRA positive)00003
HIT absent (SRA negative)3313221
% SRA positive0%0%0%0%75%