J Hematol

Journal of Hematology, ISSN 1927-1212 print, 1927-1220 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Hematol and Elmer Press Inc

Journal website http://www.thejh.org

Original Article

Volume 4, Number 2, June 2015, pages 157-163

Effect of Preoperative Autologous Blood Donation Coupled With Fluid Resuscitation on Transfusion Requirements Following Orthopedic Surgery

**Table 1.** Baseline Characteristics
	Donor (n = 91)	Non-donor (n = 91)	P-value
Age mean ± 1 SD	62.81 ± 7.80	65.52 ± 11.77	0.068
BMI mean ± 1 SD	29.50 ± 6.08	29.73 ± 6.42	0.807
Gender, n (%)
Male	49 (53.85%)	44 (48.35%)
Female	42 (46.15%)	47 (51.65%)
Joint, n (%)
Knee	46 (50.55%)	44 (48.35%)
Hip	45 (49.45%)	47 (51.65%)

Table 1. Baseline Characteristics

Donor (n = 91)

Non-donor (n = 91)

P-value

Age mean ± 1 SD

62.81 ± 7.80

65.52 ± 11.77

0.068

BMI mean ± 1 SD

29.50 ± 6.08

29.73 ± 6.42

0.807

Gender, n (%)

Male

49 (53.85%)

44 (48.35%)

Female

42 (46.15%)

47 (51.65%)

Joint, n (%)

Knee

46 (50.55%)

44 (48.35%)

Hip

45 (49.45%)

47 (51.65%)

**Table 2.** Relative Risk (RR) for Receiving at Least 1 Unit of Transfused Blood Postoperatively
	n	Unadjusted RR (95% CI)	Adjusted RR (95% CI)
Donor status
Non-donor	91	Reference	Reference
Donor	91	1.778 (1.079 - 2.928)	2.817 (1.301 - 6.100)
Index joint
Knee	90	Reference	Reference
Hip	92	2.784 (1.589 - 4.880)	3.472 (1.530 - 7.881)
Age
< 60	58	Reference	Reference
60 - 69	71	1.194 (0.646 - 2.207)	1.589 (0.631 - 4.000)
≥ 70	53	1.515 (0.825 - 2.784)	2.641 (0.882 - 7.031)
BMI
≤ 25.0	40	Reference	Reference
25.1 - 30.0	63	0.794 (0.470 - 1.341)	0.619 (0.246 - 1.554)
30.1 - 35.0	50	0.450 (0.223 - 0.909)	0.315 (0.108 - 0.922)
> 35.0	29	0.431 (0.178 - 1.042)	0.290 (0.076 - 1.107)
HES
No	151	Reference	Reference
Yes	31	2.088 (1.311 - 3.324)	2.616 (1.000 - 6.845)

Table 2. Relative Risk (RR) for Receiving at Least 1 Unit of Transfused Blood Postoperatively

Unadjusted RR (95% CI)

Adjusted RR (95% CI)

Donor status

Non-donor

Reference

Donor

1.778 (1.079 - 2.928)

2.817 (1.301 - 6.100)

Index joint

Knee

Reference

Hip

2.784 (1.589 - 4.880)

3.472 (1.530 - 7.881)

Age

< 60

Reference

60 - 69

1.194 (0.646 - 2.207)

1.589 (0.631 - 4.000)

≥ 70

1.515 (0.825 - 2.784)

2.641 (0.882 - 7.031)

BMI

≤ 25.0

Reference

25.1 - 30.0

0.794 (0.470 - 1.341)

0.619 (0.246 - 1.554)

30.1 - 35.0

0.450 (0.223 - 0.909)

0.315 (0.108 - 0.922)

> 35.0

0.431 (0.178 - 1.042)

0.290 (0.076 - 1.107)

HES

151

Reference

Yes

2.088 (1.311 - 3.324)

2.616 (1.000 - 6.845)

**Table 3.** Hemoglobin Values in Perioperative Period
	Donor (mean ± 1 SD)	Non-donor (mean ± 1 SD)	P-value
Preoperative	14.26 ± 1.06	13.89 ± 1.24	0.034
Postoperative day 0	11.75 ± 1.24	12.37 ± 1.43	0.002
Postoperative day 1	10.18 ± 1.14	10.68 ± 1.38	0.009
Postoperative day 2	10.02 ± 1.05	10.12 ± 1.27	0.562
Average postoperative trough	9.71 ± 1.06	9.67 ± 1.35	0.846
Day of lowest hemoglobin	1.99 ± 0.91	2.54 ± 1.09	< 0.001
Triggering hemoglobin for first transfusion	8.80 ± 0.53	8.05 ± 0.47	< 0.001

Table 3. Hemoglobin Values in Perioperative Period

Donor (mean ± 1 SD)

Non-donor (mean ± 1 SD)

P-value

Preoperative

14.26 ± 1.06

13.89 ± 1.24

0.034

Postoperative day 0

11.75 ± 1.24

12.37 ± 1.43

0.002

Postoperative day 1

10.18 ± 1.14

10.68 ± 1.38

0.009

Postoperative day 2

10.02 ± 1.05

10.12 ± 1.27

0.562

Average postoperative trough

9.71 ± 1.06

9.67 ± 1.35

0.846

Day of lowest hemoglobin

1.99 ± 0.91

2.54 ± 1.09

< 0.001

Triggering hemoglobin for first transfusion

8.80 ± 0.53

8.05 ± 0.47

< 0.001

**Table 4.** Blood Loss and Fluid Administration
	Donor status	Transfusion status
EBL: total estimated blood loss during surgery and immediate post-operative phase.
EBL	275.8	323.6	0.348	477.4	232.4	0.002
IV fluid given (mL)
Day of surgery	3,021.60	2,945.40	0.442	3,106.90	2,936.80	0.125
Post-operative day 1	1,798.20	1,917.80	0.185	1,991.80	1,807.30	0.067
Post-operative day 2	330.5	565.2	0.007	559.8	405.5	0.112
Total preceding transfusion	4,011.50	4,980.60	0.029	NA	NA	NA

Table 4. Blood Loss and Fluid Administration

Donor status

Transfusion status

Donor (n = 91)

Non-donor (n = 91)

P-value

Transfused (n = 50)

Non-transfused (n = 132)

P-value

EBL: total estimated blood loss during surgery and immediate post-operative phase.

EBL

275.8

323.6

0.348

477.4

232.4

0.002

IV fluid given (mL)

Day of surgery

3,021.60

2,945.40

0.442

3,106.90

2,936.80

0.125

Post-operative day 1

1,798.20

1,917.80

0.185

1,991.80

1,807.30

0.067

Post-operative day 2

330.5

565.2

0.007

559.8

405.5

0.112

Total preceding transfusion

4,011.50

4,980.60

0.029