Figure 1. Kaplan-Meier plot (time-dependent Cox regression univariate analysis) comparing overall survival across USR, EF-SD, and LF-SD. USR: upfront steroid refractory; EF-SD: early-failure steroid-dependent; LF-SD: late-failure steroid-dependent.
| Journal of Hematology, ISSN 1927-1212 print, 1927-1220 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Hematol and Elmer Press Inc |
| Journal website https://www.thejh.org |
Letter to the Editor
Volume 10, Number 1, February 2021, pages 35-39
Similar Outcomes in Early-Failure Steroid-Dependent Compared to Upfront Steroid Refractory Acute Graft-Versus-Host Disease Following Allogeneic Hematopoietic Cell Transplant
Figures
Table
| USR (n = 41) | SD all (n = 60) | EF-SD (n = 24) | LF-SD (n = 36) | |
|---|---|---|---|---|
| F: female; M: male; GvHD: graft-versus-host disease; USR: upfront steroid refractory; SD: steroid dependent; EF-SD: early-failure steroid-dependent; LF-SD: late-failure steroid-dependent; IQR: interquartile range; CMV: cytomegalovirus. | ||||
| Age at transplant, median (IQR) | 52 (42 - 59) | 44 (32 - 53) | 41 (30 - 48) | 46 (35 - 54) |
| Recipient sex | ||||
| F | 37% (15) | 57% (34) | 58% (14) | 56% (20) |
| M | 63% (26) | 43% (26) | 42% (10) | 44% (16) |
| Donor type | ||||
| Related | 46% (19) | 33% (20) | 29% (7) | 36% (13) |
| Unrelated | 54% (22) | 67% (40) | 71% (17) | 64% (23) |
| Graft type | ||||
| Bone marrow | 20% (8) | 17% (10) | 25% (6) | 11% (4) |
| Umbilical cord | 7% (3) | 10% (6) | 8% (2) | 11% (4) |
| Peripheral blood | 73% (30) | 73% (44) | 67% (16) | 78% (28) |
| Sex mismatch (D/R) | ||||
| F/F | 16% (6) | 23% (13) | 13% (3) | 30% (10) |
| F/M | 24% (9) | 18% (10) | 22% (5) | 15% (5) |
| M/F | 21% (8) | 36% (20) | 44% (10) | 30% (10) |
| M/M | 40% (15) | 23% (13) | 22% (5) | 24% (8) |
| Missing | 0% (0) | 0% (0) | 0% (0) | 0% (0) |
| CMV serostatus (D/R) | ||||
| N/N | 13% (5) | 16% (9) | 17% (4) | 15% (5) |
| N/P | 13% (5) | 12% (7) | 13% (3) | 12% (4) |
| P/N | 40% (15) | 34% (19) | 30% (7) | 36% (12) |
| P/P | 26% (10) | 36% (20) | 35% (8) | 36% (12) |
| Missing | 8% (3) | 2% (1) | 4% (1) | 0% (0) |
| ABO match | ||||
| Match | 47% (18) | 48% (27) | 35% (8) | 58% (19) |
| Mismatch | 47% (18) | 50% (28) | 61% (14) | 42% (14) |
| Missing | 5% (2) | 2% (1) | 4% (1) | 0% (0) |
| Diagnosis | ||||
| Acute leukemia | 44% (18) | 54% (33) | 50% (12) | 58% (21) |
| Lymphoid | 20% (8) | 24% (14) | 25% (6) | 22% (8) |
| Myeloid | 27% (11) | 19% (11) | 17% (4) | 19% (7) |
| Other | 10% (4) | 4% (2) | 8% (2) | 0% (0) |
| Regimen intensity | ||||
| Myeloablative | 49% (20) | 77% (46) | 75% (18) | 78% (28) |
| Non-myeloablative or reduced intensity | 51% (21) | 23% (14) | 25% (6) | 22% (8) |