Figure 1. Bone marrow aspirate from the patient demonstrating numerous lymphocytes engulfed by a macrophage.
| Journal of Hematology, ISSN 1927-1212 print, 1927-1220 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Hematol and Elmer Press Inc |
| Journal website http://www.thejh.org |
Case Report
Volume 2, Number 2, October 2013, pages 76-78
Hepatitis C Virus Associated Hemophagocytic Lymphohistiocytosis: Case Report and Literature Review
Figure
Table
| Author | Patient | Hepatitis virus(es) | Clinical Scenario | Treatment | Outcome |
|---|---|---|---|---|---|
| DIC, disseminated intravascular coagulation; G-CSF, granulocyte-colony stimulating factor; IVIG, intravenous immunoglobulin; HD, hospital day; MOF, multi-organ failure; POD, post-operative day | |||||
| Wu et al [7] | 23 M | A, C | Acute hepatitis A with chronic hepatitis C | Parenteral steroids | Deceased due to DIC |
| Faurschou et al [6] | 28 M | B, C | Acute hepatitis C with chronic hepatitis B | Methylprednisolone, cyclosporine, G-CSF, IVIG, anti-thymocyte globulin | Deceased on HD 27 from MOF |
| Tierney et al [8] | 60 F | C | Undergoing treatment for HCV with interferon-alpha and ribavirin | Dexamethasone/IVIG, followed by etoposide | Death on HD 37 due to sepsis |
| Akamatsu et al [9] | 48 F | C | Liver transplant patient for HCV-induced cirrhosis, s/p treatment for acute rejection, with persistent HCV viremia, HLH diagnosed on POD 50 | Interferon-α and ribavirin, G-CSF | Remission of HLH, then deceased on POD 88 from graft failure |
| Pease and Mathew (this report) | 46 M | C | No simultaneous co-infections or treatment-related immunomodulation | Etoposide/ dexamethasone | Remission |