Journal of Hematology, ISSN 1927-1212 print, 1927-1220 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Hematol and Elmer Press Inc
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Short Communication

Volume 10, Number 4, August 2021, pages 196-201

Platelet Aggregation Assays Do Not Reliably Diagnose Platelet Delta Granule Storage Pool Deficiency

Figure

Figure 1.
Figure 1. All patients presented with unexplained bleeding and were evaluated by both LTA and EM. This figure graphically demonstrates more than 30% of subjects with dense granule SPD have normal LTA results. For subjects with SPD, the agonist epinephrine was abnormal more often than for ADP as agonist. SPD: storage pool deficiency; LTA: luminescence transmission aggregometry; EM: electron microscopy.

Table

Table 1. Patients With Delta Granule Storage Pool Deficiency and Normal Number of Dense Granules per Platelet
 
FemalesMales
Patients with delta granule storage pool deficiency
  n = 26421846
  Normal aggregation34.4% (75/218)22% (10/46)
  Abnormal aggregation65.6% (143/218)78% (36/46)
  Age37.0 ± 18.933.5 ± 24.7
  Dense granules/platelet2.47 ± 0.702.31 ± 0.83
Patients with a normal number of dense granules per platelet
  n = 806218
  Normal aggregation50% (31/62)39% (7/18)
  Abnormal aggregation50% (31/62)61% (11/18)
  Age35.2 ± 21.529.1 ± 26.3
  Dense granules/platelet4.88 ± 0.824.79 ± 0.65