Harnessing the Immune System: An Effective Way to Manage Diffuse Large B-Cell Lymphoma

Nathan Visweshwar, Juan Felipe Rico, Robert Killeen, Arumugam Manoharan

Abstract


Diffuse large B-cell lymphoma (DLBCL) is a heterogenous hematological disorder with malignant potential controlled by immunological characteristics of the tumor microenvironment. Rapid breakthrough in the molecular pathways has made immunological approaches the main anchor in the management of DLBCL, with or without chemotherapeutic agents. Rituximab was the first monoclonal antibody approved for the treatment of DLBCL. Following rituximab that transformed the therapeutic landscape, other novel immunological agents including chimeric antigen T-cell therapy have reshaped the management of relapsed/refractory DLBCL. However, resistance and refractory state remain a challenge in the management of DLBCL. For this literature review, we screened articles from Medline, Embase, Cochrane databases and the European/North American guidelines from March 2010 through October 2022 for DLBCL. Here we discuss immunological agents that will significantly affect future treatment of this aggressive type of lymphoma.




J Hematol. 2023;12(4):145-160
doi: https://doi.org/10.14740/jh1112

Keywords


Diffuse large B-cell lymphoma; Immunotherapy; Immunomodulatory therapy; Bispecific T-cell engager antibody; Antibody drug conjugates; Checkpoint inhibitors; Chimeric antigen receptor T-cell therapy

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Journal of Hematology, bimonthly, ISSN 1927-1212 (print), 1927-1220 (online), published by Elmer Press Inc.                            
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