Acquired beta-Thalassemia as an Etiology of Microcytic Anemia in Primary Myelofibrosis

Abstract

A 62-year-old man was diagnosed as primary myelofibrosis (PMF) with Janus kinase 2 V617F mutation. He also had progressive microcytic anemia which was diagnosed as acquired β-thalassemia associated with PMF. Microcytosis is reported to be complicated with approximately a quarter of the patients with PMF; however, the etiology has not been elucidated yet. To our knowledge, this is the first report of acquired β-thalassemia developed in a patient with PMF which has a clinical significance in the diagnosis and management of anemia in a subset of the patients with PMF.




J Hematol. 2015;4(1):148-150
doi: http://dx.doi.org/10.14740/jh190w