Diagnostic Value of HbA1c Level in Behcet's Disease and Evaluation of Neutrophil-Lymphocyte Ratio, Mean Platelet Volume and Body Mass Index

Abstract

Background: Behcet's disease (BD) is a chronic systemic inflammatory disorder. T cells, neutrophils, inflammatory vasculitis and endothelial injury were implicated in the pathogenesis of BD. Hemoglobin A1c (HbA1c) is a minor component of hemoglobin to which glucose is bound, and it was reported to be associated with intima-media thickness, endothelial dysfunction and atherosclerosis in non-diabetic patients. In this study, we aimed to investigate the relationship between markers of glucose metabolism and BD in non-diabetic individuals. To the best of our knowledge, this planned study was the first evaluating the glucose metabolism with HbA1c levels and correlating it with body mass index (BMI), lipid profiles and the other inflammatory markers (mean platelet volume (MPV), neutrophil-lymphocyte ratio (NLR) and sedimentation) in BD.

Methods: Sixty-four patients and 64 controls were enrolled in this study. Clinical manifestations of the disease were recorded. Laboratory analysis including HbA1c, hemogram, hematocrit, platelet count, liver function tests, complete blood count, urine analysis, erythrocyte sedimentation rate, MPV, lipid testes including low density lipoprotein (LDL), high density lipoprotein (HDL), triglycerides and total cholesterol levels were measured. Height, weight and BMI of patients were recorded.

Results: Glucose levels were statistically higher in BD (P < 0.01). HbA1c level was evaluated, and statistically significant difference was not obtained (P = 0.9). Hemoglobin, hematocrit, platelet level and liver-urine analysis tests did not show any significant difference. Cholesterol, triglyceride, and LDL levels were statistically higher in BD group than control group (P = 0.00, P = 0.003, and P = 0.001). BMI was evaluated, and there was a significant difference in BD group (P = 0.016). NLR and sedimentation were higher in BD (P < 0.01). However, the other inflammatory marker MPV had no significant elevation.

Conclusions: There was no significant association observed between BD patients and HbA1c levels, and this was the first study investigating HbA1c levels and correlating it with other parameters.




J Hematol. 2015;4(4):219-222
doi: http://dx.doi.org/10.14740/jh230e