Anaplastic Large-Cell Lymphoma T Anaplastic Lymphoma Kinase-Positive Associated With Crohn's Disease Undergoing Treatment With Azathioprine: A Case Report

Pamela Cristina Gaspar, Manoela Lira Reis, Kaite Cristiane Peres, Renata Cristina Messores Rudolf-Oliveira, Vanessa Mengatto, Joanita Angela Gonzaga Del-Moral, Maria Claudia Santos-Silva

Abstract


Anaplastic large-cell lymphoma (ALCL) is a subgroup of non-Hodgkin lymphoma (NHL) that the etiology is not totally elucidated. Hereditary, environmental, occupational and dietary factors are believed to be related with the development of NHL. The use of some immunomodulatory drugs such as azathioprine at the treatment of Crohn's disease (CD) has been described in the literature causing NHL. We reported a clinical case of a possible association between NHL and Crohn's treatment. Furthermore, ALCL is a rare subtype of NHL, thus, it has a difficult diagnostic. So in this study we also demonstrated clinical characteristics and laboratory findings that are helpful to rapid and accurate diagnostic of ALCL.




J Hematol. 2014;3(3):91-94
doi: http://dx.doi.org/10.14740/jh118w


Keywords


Anaplastic large-cell lymphoma; Crohn’s disease; Non-Hodgkin lymphoma

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Journal of Hematology, bimonthly, ISSN 1927-1212 (print), 1927-1220 (online), published by Elmer Press Inc.                            
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