Lennert's Maze Game: A Diagnostic Hematological Challenge

Nilma Malik, Vishwanath Pattan, Waqas Jehangir, Hongxiu Luo, Yazan Vwich, Teena Mathew, Shuvendu Sen, Abdalla Yousif


Lennert lymphoma is a subset of peripheral T-cell lymphoma (PTCL) that constitutes about 30% of T-cell lymphomas. The immunophenotypes usually are positive for pan-antigens, such as CD2, CD3, CD5 or CD7. About half cases present aberrantly without the pan-antigens. This rare case opens up a new horizon of thought process, as it illustrates the clinical presentation of PTCL with aberrant hematological parameters. It emphasizes on diagnostic and treatment challenges of Lennert lymphoma presenting with a triad of eosinophilia, lactic acidosis and multi-organ thrombosis. Early treatment with chemotherapy rather than supportive measures is crucial as it has shown significant morbidity benefits.

J Hematol. 2014;3(3):89-90
doi: http://dx.doi.org/10.14740/jh165w


Lennert; Lactic acidosis; Eosinophilia; Thrombosis; Hemophagocytosis; Chemotherapy; Thrombomodulin; Prognosis

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