Acute Cutaneous Flare and Hemophagocytosis: An Unusual Presentation of Adult Anaplastic Large Cell Lymphoma

Abstract

Hemophagocytic lymphohistiocytosis (HLH), also known as hemophagocytic syndrome, is a disorder characterized by the pathologic activation and proliferation of histiocytes, mainly in the bone marrow, liver, spleen and lymph nodes. Although HLH is frequently associated with lymphomas, it is a rare presentation of anaplastic large cell lymphoma (ALCL). We report a case of anaplastic large cell lymphoma (ALCL) in an adult manifested as generalized cutaneous nodules and fulminant hemophagocytosis.




doi: http://dx.doi.org/10.4021/jh35e