Large Vessel Vasculitis as a Possible Mechanism of Vascular Side Effects of Ponatinib: A Case Report

Klaus Hirschbuehl, Andreas Rank, Tim Pfeiffer, Tina Schaller, Thomas Haeckel, Joerg Roeling, Dmytro Vlasenko, Martin Trepel, Christoph Schmid

Abstract


Arterial occlusive events (AOEs) such as cerebrovascular, cardiovascular and peripheral arterial events are known side effects of ponatinib, assumed due to the rapid development and increase of arteriosclerosis, while the definitive pathomechanisms therefore are still unclear. We present a case of clinically apparent large vessel vasculitis and discuss this phenomenon as a possible mechanism of AOEs beside arteriosclerosis.




J Hematol. 2019;8(2):83-85
doi: https://doi.org/10.14740/jh519

Keywords


Ponatinib; Arterial occlusive events; Vasculitis

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Journal of Hematology, bimonthly, ISSN 1927-1212 (print), 1927-1220 (online), published by Elmer Press Inc.                            
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